projects and lines of research

Since our foundation, Research and Development, together with Innovation, has been in our DNA. In this way, we are involved in numerous projects both nationally and internationally.

Biomarker determination using biosensors

CQS is currently participating in the international project H2020-ALLERSCREENING (Point-of-care device based on KETs for diagnosis of food allergies) ref 768641 related to the diagnosis of food allergies, framed in the Horizon Programme H2020;

The aim is to use a novel optical biosensor as an analytical tool for the multiplex detection of specific IgE antibodies against molecular allergens.

In this line of biosensors and immunoassays, CQS can be involved in general biofunctionalisation tasks of surfaces and nanoparticles for implementation in immunodetection systems, as well as in the fine-tuning of experimental assay conditions and their validation.

For the development and clinical validation of this sensor platform, 10 European partners are collaborating:

Universidad Politécnica de Madrid (Spain)

BIO Optical Detection SL (Spain)

Microfluidic Chipshop GMBH (Germany)

Andalusian Health Service (Spain)

San Carlo Clinic (Italy)

Antwerpen University (Belgium)

Medical University of Vienna (Austria)

University Hospital Rechts der Isar of the Technical University of Munich (Alemania)

Consejería de Salud de la Junta de Andalucía (Andalusian Regional Ministry of Health) (Spain)

Consulting Químico Sanitario SL (Spain)

Previously, CQS has participated in the national project RETOS-ATAPOC (Development and clinical validation of a device for the diagnosis and monitoring of food allergies and food tolerances) ref RTC-2015-3273-1 financed by the ministry of economy and competitiveness (currently ministry of science and innovation) and co-financed with funds FEDER (European Regional Development Fund)

Determination of biomarkers by mass spectrometry

CQS has a triple quadrupole mass spectrometer coupled to liquid chromatography (HPLC-MS/MS), powerful equipment for robust and simultaneous quantification of various analytes. Detection of isoprostanes, sugars, steroids or drugs in clinical samples are some examples of methodologies developed by CQS.

CQS can develop and optimise spectrometric methods for various applications, making the application range of HPLC-MS/MS very wide.

clinical studies

Collaboration in Clinical Research Studies

Research is one of the strategic axes of CQS, with special emphasis on the development of translational research lines. Thanks to this activity, CQS has extensive experience as a collaborating laboratory in clinical research studies both nationally and internationally.

Study name: AMC3 SE2017/00019
Participating entity/s: Instituto IMDEA Alimentación
City of the entity: MADRID, Community of Madrid, Spain
Start date: 2017

Name of the study: General scoop SE2017/00231
Participating entity/s: Institute IMDEA Food
City of the entity: MADRID, Community of Madrid, Spain
Start date: 2017

Name of the study: INTALIM SE2017/000517
Participating entity/s: Institute IMDEA Food
City of the entity: MADRID, Community of Madrid, Spain
Start date: 2017

Name of the study: TuttiPasta Studio (Scoop 5) SE2016/001077
Participating entity/s: Institute IMDEA Food
City of the entity: MADRID, Community of Madrid, Spain
Start date: 2016

Name of the study: Scoop 4 ES2016/000580
Participating organisation(s): Institute IMDEA Food
City of the entity: MADRID, Community of Madrid, Spain
Start date: 2016

Name of the study: AMC2 SE2016/000719
Participating organisation(s): Institute IMDEA Food
City of the entity: MADRID, Community of Madrid, Spain
Start date: 2016

Name of the study: Scoop 3 SE2016/000159 Health care activity Clinical research studies
Participating organisation(s): Institute IMDEA Food
City of the entity: MADRID, Community of Madrid, Spain
Start date: 2016

Name of the study: SE2016/000463
Participating organisation(s): Institute IMDEA Food
City of the entity: MADRID, Community of Madrid, Spain
Start date: 2016

Name of the study: Predimed Plus SE2016/000463
Participating organisation(s): Institute IMDEA Food
City of the entity: MADRID, Community of Madrid, Spain
Start date: 2016

Name of the study: Scoop 2 SE2015/001128
Participating organisation(s): Institute IMDEA Food
City of the entity: MADRID, Community of Madrid, Spain
Start date: 2015

Name of the study: Scoop 1 SE2015/000903
Participating organisation(s): Institute IMDEA Food
City of the entity: MADRID, Community of Madrid, Spain
Start date: 2015

Name of the study: INNASAULI Studio
Participating organisation(s): Institute IMDEA Food
City of the entity: MADRID, Community of Madrid, Spain
Start date: 2015

Name of the study: MiroBeer Studio
Participating organisation(s): Institute IMDEA Food
City of the entity: MADRID, Community of Madrid, Spain
Start date: 2015

Name of the study: Capsa SE2014/000019
Participating organisation(s): Institute IMDEA Food
City of the entity: MADRID, Community of Madrid, Spain
Start date: 2014

Name of the study: TANSNIP Study 2015/ES/06
Participating entity/s: National Cardiovascular Research Centre (CNIC)
City of the entity: MADRID, Community of Madrid, Spain
Start date: 2015

Name of the study: SPFS Study 2014/EU/01
Participating entity/s: National Cardiovascular Research Centre (CNIC)
City of the entity: MADRID, Community of Madrid, Spain
Start date: 2014

Name of the study: Telomere Study 2012/ES/36
Participating entity/s: National Cardiovascular Research Centre (CNIC)
Name of the study: Telomere Study 2012/ES/36
Start date: 2012

Name of the study: SPFS Study 2010/EU/03
Participating entity/s: National Cardiovascular Research Centre (CNIC)
Name of the study: Telomere Study 2012/ES/36
Start date: 2010

Study name: Presiden Study
Participating organisation(s): Bayer HealthCare
Location: MADRID, Community of Madrid, Spain
Start date: 2014

Name of the study: SER 4-2013
Participating entity/s: FHealth Research Foundation of the Balearic Islands
Name of the study: Telomere Study 2012/ES/36
Start date: 2013

Name of the study: NUSDEPECO13002649/1
Participating entity/s: National Universty of Singapure
Name of the study: Telomere Study 2012/ES/36
Start date: 2013

Name of the study: Children and Environment (INMA)
Participating entity/s: Biodonisti
Name of the study: Telomere Study 2012/ES/36
Start date: 2007

Other

In general, we are working on the development of analytical methodologies for the determination of biomarkers of interest, in order to make the diagnosis of different pathologies more efficient and simple. Our lines are diverse and are related to oxidative stress, allergies, hypogonadism or covid-19, among others.

In addition to biosensors and mass spectrometry, our laboratory has automated analysers and hundreds of determinations that can work at the service of our R&D&I area, thus reinforcing the clinical support of our projects.

It is worth noting that CQS is an innovative SME, a biobank of samples and accredited according to standard 17025, an ideal environment for the development of quality clinical research activities.

Some previous regional and national projects:

Biomarker quantification in non-alcoholic steatohepatitis (NASH)

Identification of Biomarkers for Non-Invasive Diagnosis of Non-Alcoholic Steatohepatitis, Molecular Targets and New Treatment Strategies

Organisation and development of a Mass Spectrometry Unit for epidemiological studies. Biomarkers of oxidation

Organisation, development and technical management of a biobank for long-term epidemiological studies.

Feasibility study of an analytical method for the detection of Multiple Sclerosis.

E-aid for efficient R&D&I management of a small and medium-sized enterprise

Implementation of a quality management system according to the UNE-EN-ISO 17025 standard